孙江涛教授课题组在Angewandte Chemie, International Edition发表研究论文

发布时间:2014-11-12浏览次数:553

Gold(I)-Catalyzed Diazo Cross-Coupling: A Selective and Ligand-Controlled Denitrogenation/Cyclization Cascade

Guangyang Xu, Chenghao Zhu, Dr. Weijin Gu, Dr. Jian Li, Prof. Dr. Jiangtao Sun*

Article first published online: 10 NOV 2014 DOI:10.1002/anie.201409845

Abstract

An unprecedented gold-catalyzed ligand-controlled cross-coupling of diazo compounds by sequential selective denitrogenation and cyclization affords N-substituted pyrazoles in a position-switchable mode. This novel transformation features selective decomposition of one diazo moiety and simultaneous preservation of the other one from two substrates. Notably, the choice of the ancillary ligand to the gold complex plays a pivotal role on the chemo- and regioselectivity of the reactions.

http://onlinelibrary.wiley.com/doi/10.1002/anie.201409845/abstract