沈美华博士课题组在Oranic Letters发表研究论文

发布时间:2017-07-08浏览次数:30

Stereoselective Construction of Bridged trans-aza-Bicyclo[7/6,3/2,1]alkenyl Imines through Ring Expansion aza-Cope Rearrangement

Dr. Mei-Hua Shen, Ke Xu, Chu-Han Sun and Dr. Hua-Dong Xu

  

Article first published online: 03 NOV 2015 | DOI: 10.1021/acs.orglett.5b02798

全文键连:http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b02798?journalCode=orlef7&quickLinkVolume=17&quickLinkPage=5598&selectedTab=citation&volume=17

  

Abstract: A highly stereoselective method for efficient synthesis of unprecedented bridged bicyclo[7/6,3/2,1]alkenyl amidines is described using cyclic N-allyl-aminoalkyne as a substrate. A ketenimine formation/cyclization/aza-Cope rearrangement cascade proceeds either with or without the aid of external DIPEA depending on substrate basicity. Fused bicycloamidines are also obtained via the same protocol using different N-allyl cyclic aminoalkynes.