2019年5月31日美国麻省波士顿大学张炜教授学术报告

发布时间:2019-05-15浏览次数:13


报告题目:Small Molecule Inhibitors & Probes for Druggable Targets(小分子抑制剂与药物靶点探针)

报告时间:2019531日(周五)下午13:30

报告地点:天润科技大厦A614报告厅

报 告 人:张炜 (Wei Zhang)博士, 美国麻省波士顿大学教授

  

Abstract:This presentation highlights our recent effort on the development of green and highly efficient methods for organic synthesis and asymmetric catalysis. A series of technologies including one-pot synthesis, multicomponent reactions, and organocatalysis are employed to maximize synthetic efficiency for diverse heterocyclic scaffolds. Through the collaboration with Harvard and other medical schools in US and Europe, our compounds have been integrated to a number of drug discovery programs. Several lead compounds have been developed for druggable targets such bromodomains (BET, CBP), kinases (PLK1), and MDM2 related to cancer and other targets (HIV-1 & RORgt) related to immune and inflammation diseases. 

报告人介绍: 张炜是南京大学学士,美国匹兹堡大学化学博士及博士.历任美国杜邦公司研究员,美国氟相技术公司开发部主任.现任美国麻省波士顿大学化学系正教授及绿色化学中心主任.是国际氟相化学,自由基化学,组合化学和绿色化学领域的人物.已发表论文200多篇.2012出版“Green Techniques for Organic and Medicinal Chemistry”(Wiley,2018第二版). 6项美国专利及专利申请(新农药,氟相技术及,HIV新药).19个国家及地区作过200次学术讲座和会议报告,7个国际期刊编辑(),3个国际绿色化学协会委员.美国总统绿色化学挑战奖评委员会委员.2015在意大利荣获国技术 (International Fluorous Technology Award).目前正与哈佛及柏林大学医学院合作开发艾滋病新药.