药物科学与技术团队

药物科学与技术团队

药物科学与技术团队是药学院新建团队，汇集了一批有志于科研的青年教师，各自在自己的领域里有一席之地；团队学术带头人是国内药物合成专家。团队经费充足，设备先进。

联系方式：fxqfw@163.com  冯筱晴

研究方向包括：

1．          药物化学：小分子化合物的设计、合成及生物活性研究，致力于基础研究，发现活性好的化合物以进一步发展成药物。

2．          有机合成工艺学：以产业化为导向，解决工业生产中遇到的实际工艺问题。如合成路线优化，降低成本，降低三废排放等。

3．          有机合成方法学研究：属于基础研究范畴，研究新反应新试剂新机理。

4．          工业酶催化：利用酶催化的单一性解决工业生产中的转化问题。

近期发表论文：

1)       Han, J.; Han, J.; Chen, S.; Zhong, T.; He, Y.; Yang, X.; Wang, G.; Zhu, C. Xie, J. Photoinduced manganese-catalysed hydrofluorocarbon- functionalization of alkenes. Nat.Syn.2022, 1, 475-486.

2)       Han, J.; Xie, J. Tertiary amine synthesis by radical carbonyl alkylative amination. Chem. 2020, 6, 1046-1055.

3)       Han, J.; Zhang, L.; Zhu, Y.; Zheng, Y.; Chen, X.; Huang, Z.-B.; Shi, D.-Q.; Zhao, Y. Highly regioselective meta arylation of oxalyl amide-protected β-arylethylamine via theCatellani reaction. Chem. Commun.2016, 52, 6903-6906.

4)       Han, J.; Liu, P.; Wang, C.; Wang, Q.; Zhang, J.; Zhao, Y.; Shi, D.; Huang, Z.; Zhao, Y. Oxalyl amide assisted palladium-catalyzed arylation of C(sp2)-H bond at the δ position. Org. Lett.2014, 16, 5682-5685.

5)       Han, J.; Wang N.; Huang, Z.-B.; Zhao, Y.; Shi, D.-Q. Ruthenium-catalyzedcarbonylation of oxalyl amide-protected benzylamines with isocyanate as the carbonylsource. J. Org. Chem.2017, 82, 6831-6839.

6)       Han, J.; Zheng, Y.; Wang, C.; Zhu, Y.; Huang, Z.-B.; Shi, D.-Q.; Zeng, R.; Zeng, R.; Zhao, Y. Pd-catalyzed coupling of γ-C(sp3)-H bonds of oxalyl amide-protected amino acids withheteroaryl and aryl iodides. J. Org. Chem.2016, 81, 5681-5689.

7)       Han, J.; Zheng, Y.; Wang, C.; Zhu, Y.; Shi, D.-Q.; Zeng, R.; Huang, Z.-B.; Zhao, Y. Palladium-catalyzed oxalyl amide-directed γ-arylation of aliphatic amines. J. Org. Chem.2015, 80, 9297-9306.

8)       Han, J.; Wang N.; Huang, Z.-B.; Zhao, Y.; Shi, D.-Q. Pd-catalyzed regioselectivesequential meta-, ortho-C–H functionalization of arenes: a predictable approach to thesynthesis of polysubstituted β-arylethylamines. Org. Biomol. Chem. 2017, 15, 5112-5116.

9)       Huang, R.; Wang, M.; Deng, H.; Xu, J.; Yan, H.; Zhao, Y.; Shi, Z. Stereospecific nickel-catalyzed [4+2] heteroannulation of alkynes with aminophosphanes. Sci Adv.2023, 9, 8638.

10)    Huang, R.; Zhao, W.; Xu, S.; Xu, J.; Li,, C.; Lu C.; Yan, H. Photoredox B-H functionalization to selective B-N(sp3) coupling of nido-carborane with primary and secondary amines. Chem Commun. 2021, 57, 8580-8583.

11)    Huang, R.; Yang,Y.; Wang,D.; Zhang,L.; Wang, D. Where Does Au Coordinate to aN-(2-Pyridiyl)benzotriazole: Gold Catalyzed Chemoselective Dehydrogenation and Borrowing Hydrogen Reaction. Org. Chem. Front.2018, 5, 203–209.

12)    Huang, R., Fu, Y.; Zeng, W.; Zhang, L.; Wang, D. The Facile Approach to Fabricate GoldNanoparticles and Their Application on the Hydration and Dehydrogenation Reactions. J. Organomet. Chem.2017, 851, 46-51.