马晓明 简介

联系方式

常州大学药学院

江苏省常州市科教城测试实验楼A座804，邮编213164

Email：mxm.wuxi@cczu.edu.cn

主要教育和工作经历

2020.12 常州大学药学院讲师/硕士生导师

2017.10 美国麻省州立大学，Wei Zhang(张炜)课题组，访问学者，从事多组分反应研究

2013.12 常州大学制药与生命科学学院讲师

2013.10 南京理工大学化学工程与技术(应用化学)  博士

2007.07南京理工大学高分子材料与工程学士

教学经历

主讲《制药反应与分离工程基础》《制药过程安全与环保》《制药设备与车间设计课程设计》和制药工程专业实验、专业生产实习等理论和实践类课程。

科研方向

1.      微通道/连续流工艺开发及其工程化技术

2.      多组分反应绿色高效合成杂环化合物

近期代表性论文

1.      Xiaoming Ma, Weiqi Qiu, Li Liu, Xiaofeng Zhang, JohnMark Awad, Jason Evans, Wei Zhang. Synthesis of tetrahydropyrrolothiazoles through one-pot and four-component N,S-acetalation and decarboxylative [3+2] cycloaddition, Green Synthesis & Catalysis, 2021, doi：10.1016/j.gresc.2020.11.001

2.      Guixiang Yang, Ye Liu, Liqun Wang, Yue Zhang, Xiaoming Ma* and Wei Zhang*. Diastereoselective synthesis of hexahydropyrrolo[2,1-a]isoquinolines by [3+2] cycloaddition and cyclative Heck alkyne hydroarylation, Tetrahedron Lett., 2021, Doi: 10.1016/j.tetlet.2021.152859

3.      Xiaoming Ma, Xiaofeng Zhang, John Mark Awad, Guoshu Xie, Weiqi Qiu, Rachel E Muriph and Wei Zhang. Sequential decarboxylative [3+2] cycloaddition and Staudinger/aza-Wittig reactions for diastereoselective synthesis of tetrahydro-pyrroloquinazolines and tetrahedro-pyrrolobenzodiazepines, Tetrahedron Lett., 2020, 61, 151392.

4.      Xiaoming Ma, Suzhi Meng, Xiaofeng Zhang, Qiang Zhang, Shenghu Yan, Yue Zhang and Wei Zhang. Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines via three-component [3 + 2] cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions, Beilstein J. Org. Chem.,2020, 16, 1225–1233.

5.      Xiaoming Ma, Xiaofeng Zhang, John Mark Awad, Guoshu Xie, Weiqi Qiu and Wei Zhang. One-pot synthesis of tetrahydropyrrolobenzodiazepines and tetrahydropyrrolobenzodiazepinones through sequential 1,3-dipolar cycloaddition/N-alkylation (N-acylation)/Staudinger/aza-Wittig reactions, Green Chem., 2019, 21, 4489–4494.

6.      Xiaoming Ma, Xiaofeng Zhang, Weiqi Qiu, Wensheng Zhang, Bruce Wan, Jason Evans and Wei Zhang. One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions, Molecules, 2019, 24, 601.

7.      Xiaoming Ma, Xiaofeng Zhang, Guoshu Xie, John Mark Awad and Wei Zhang. One-pot diastereoselective synthesis of tetrahydroepimino-benzo[b]azocines through sequential [3+2]-cycloaddition and Staudinger-aza-Wittig reactions, Tetrahedron Lett., 2019, 60, 151127.

8.      Sanjun Zhi, Xiaoming Ma and Wei Zhang. Consecutive multicomponent reactions for the synthesis of complex molecules,Org. Biomol. Chem., 2019, 17, 7632-7650. (Review Article)

9.      Xiaofeng Zhang, Xiaoming Ma, Weiqi Qiu, Jason Evans and Wei Zhang. Cascade Knoevenagel and aza-Wittig reactions for the synthesis of substituted quinolines and quinolin-4-ols, Green Chem., 2019, 21, 349–354.