沈美华 简介

发布时间:2017-05-15浏览次数:110

Meihua SHEN(沈美华) 博士 副教授 硕导

CONTACT

Schoolof Pharmaceutical and Life Sciences                    

ChangzhouUniversity (常州大学制药与生命科学学院)

Changzhou,Jiangsu 213164, China

Cell: 15851952436

Email Addressshenmh@cczu.edu.cn

  

RESEARCH INTERESTS:

Free Radical Chemistry, Organometallic Chemistry for synthesis ofsmall molecules with important biological activities. (运用新颖的自由基方法或金属有机化学方法合成具有生物活性的药物小分子)

  

PROFESSIONAL EXPERIENCE:

2012-presentAssociate Professor                

School of Pharmaceutical and Life Sciences, ChangzhouUniversity, China.                

2010-2012Senior Research Scientist                

Shanghai ChempartnerCO., LTD. (上海睿智化学研究有限公司)                

2008-2009Postdoctoral Research Associate                

Chemistry Department,University of Wisconsin-Madison, USA. (威斯康星大学-麦迪逊分校)

2007-2008Postdoctoral Research Associate                

Chemistry Department,University of Illinois at Chicago, USA. (伊利诺依大学-芝加哥分校)

2000Chemical Engineering Internship                

Jilin Chemical Industrial Co., Ltd., China. (吉林化工)

  

EDUCATIONAL BACKGROUND:

2005Ph.D in Organic Chemitry,Shanghai Institute of Organic Chemistry (SIOC),Chinese Academy of Sciences(Shanghai, P. R. China)

(中国科学院上海有机化学研究所)

2000Bachelor inChemistry, Northeast Normal University (Changchun,P. R. China)

(东北师范大学)

  

RECENT PUBLICATIONS:

1.Hao Zhou, Mei-Hua Shen*Hua-Dong Xu*. Evolution of the Aza-Diels-Alder reaction of 2H-azirines.Synlett Review2016, 27, 2171-2177.

2.Hua-Dong Xu*, Hao Wu, Chun Jiang, Peng Chen, Mei-Hua Shen*. Chemo-, regio-, andstereoselective hydroboration of conjugated enyne alcohol/amine: facilesynthesis of Z,Z-/Z,E-1,3-dien-1/2-ylboronic ester bearing hydroxyl/aminogroup. Tetrahedron Lett. 2016, 57(26), 2915-2918.

3.Xiao-Long Lu, Ya-Ting Liu,Qiang-Xia Wang, Mei-Hua Shen*, Hua-Dong Xu*. Straightforward regioselective construction of3,4-dihydro-2H-1,4-thiazine by rhodium catalysed [3+3] cycloaddition ofthiirane with 1-sulfonyl-1,2,3-triazole: a pronounced acid additive effect. Org.Chem. Front.,2016,3(6),725-729.

4.Mei-Hua Shen*,Mei Han, Hua-Dong Xu*. One-Pot Conversion of N‑Allyl-α-cyano Estersto α‑Allyl-α-cyano Lactams through aHydrolysis/Ketene Formation/Cyclization/Claisen Rearrangement Sequence.Org. Lett. 2016, 18(5), 889-891.

5.Hua-Dong Xu*, Hao Zhou, Ying-Peng Pan, Xin-Tao Ren, Hao Wu, Mei Han, Run-Ze Han, Mei-Hua Shen*.Stereoselective Synthesis of Polycycles Containing an Aziridine Group:Intramolecular aza-Diels-Alder Reactions of Unactivated 2H-Azirines withUnactivated Dienes. Angew. Chem., Int. Ed. 2016, 55(07), 2540-2544.

6.Mei-Hua Shen*, KeXu, Chu-Han Sun, Hua-Dong Xu. Facile synthesis of aza-spirocyclopropanyloxindoles by the reaction of 3-(2-bromoethyl)-indole with2,3-dimethylimidazole-1-sulfonyl azide triflate.Org. Biomol. Chem., 2016,14(04),1272-1276.

7.Mei-HuaShen,* Xiao-Long Lu, Hua-Dong Xu*. Copper(II) acetate catalysed ring-openingcrosscoupling of cyclopropanols with sulfonyl azides. RSC Adv. 2015, 5(120),98757-98761.

8.Mei-Hua Shen*, KeXu, Chu-Han Sun, Hua-Dong Xu*. Stereoselective Construction of Bridgedtrans-aza-Bicyclo[7/6,3/2,1]alkenyl Imines through Ring Expansion aza-CopeRearrangement. Org.Lett. 2015, 17(22),5598-5601.

9.Hua-DongXu*, Ying-Peng Pan, Xin-Tao Ren, Ping Zhang, Mei-Hua Shen*. A one-pot construction of acridones by rhodiumcatalyzed reaction of N-phenyl-2-(1-sulfonyl-1H-1,2,3-triazol-4-yl)aniline. Tetrahedron Lett. 2015, 56(48), 6734-6737.

10.Mei-Hua Shen*, Ke Xu, Chu-Han Sun, Hua-Dong Xu*.The Reaction of2,3-Dimethylimidazole-1-sulfonyl Azide Triflate with 3-Substituted Indoles:Reactivity and Scope. Org. Lett. 2015, 17(15), 3654-3657.

11.Mei-Hua Shen*, Ying-Peng Pan, Zhi-Hong Jia, Xin-TaoRen, Ping Zhang, Hua-Dong Xu*. An efficient approach to 1,2,3-trisubstituted indoleviarhodium catalyzed carbene Csp3–Hbond insertion. Org. Biomol. Chem., 2015,13(17),4851-4854.

12.Mei-Hua Shen*, Ying-Peng Pan, Zhi-Hong Jia, Xin-TaoRen, Ping Zhang, Hua-Dong Xu*. An efficient approach to 1,2,3-trisubstituted indoleviarhodium catalyzed carbene Csp3–Hbond insertion. Org. Biomol. Chem., 2015,13(17),4851-4854.

13.Hua-Dong Xu*,Ke Xu, Hao Zhou, Zhi-Hong Jia, Hao Wu, Xiao-Long Lu,Mei-HuaShen*. Ring-Strain-DrivenCatalytic Carbene Formation-Cyclopropanation-Aza-Cope Rearrangement Cascade: AFacile Entry to Fused Dihydroazepines from 1,3-Dienyltriazoles. Synthesis 2015,47(05), 641-646.

14.Hua-Dong Xu*, Ke Xu, Qing Zheng, Wei-Jie He, Mei-Hua Shen*, Wen-Hao Hu. Step-economyetherification of acylated alcohols. Tetrahedron Lett. 2014, 55(50), 6836-6838.

15.Hua-Dong Xu*, Ke Xu, Zhi-Hong Jia, HaoZhou, Pan Jiang, Xiao-Long Lu, Ying-Peng Pan, Hao Wu, Yun Ding, Mei-Hua Shen*,Xian-Hua Pan. Substituent Enabled Divergent Synthesis of N-Heterocycles: aMetal Carbene Approach Involving Intramolecular Carbene Interception. Asian J. Org. Chem.2014, 3(11), 1154-1158.

16.Hua-Dong Xu*, Zhi-Hong Jia, Ke Xu, MeiHan, Sai-Nan Jiang, Jing Cao, Jia-Cheng Wang, Mei-Hua Shen*. Copper-CatalyzedCyclization/aza-Claisen Rearrangement Cascade Initiated by KetenimineFormation: An Efficient Stereocontrolled Synthesis of α-Allyl Cyclic Amidines.Angew. Chem., Int. Ed. 2014, 53(35), 9284-9288.

17.Hua-Dong Xu*, Mao-Qiang Cai, Wei-JieHe, Wen-Hao Hu, Mei-Hua Shen*. Interception of benzynewith thioethers:a facile access to sulfur ylides under mild conditions. RSC Adv. 2014, 4(15), 7623-7626.