徐德锋 简介

发布时间:2017-05-15浏览次数:108

徐德锋 博士教授 硕导

CONTACT(联络信息):  

DEFENG XU ( 徐德锋)  

School of Pharmaceutical and Life Sciences, Changzhou University

Changzhou, Jiangsu 213164,China

Tel:(0519) 85281008

Email: markxu@cczu.edu.cn

  

研究生培养

研究生培养是我们的重要任务。我们欢迎对制药工程、药物化学、化学生物学、化学和制药学具有浓厚兴趣、基础知识扎实、并乐于勤奋钻研的学生加入我们,欢迎药学类、化学化工、以及生命科学类和医学类来源的考生报考。本人具有企业、研究所、高校和海外进修经历,具有教授,研究员和研究员高级工程师三大系列(教学、研究和工程)正高级职称。热忱欢迎与我们直接联系进行相关咨询答疑(徐德锋markxu@cczu.edu.cn),你们的致电是我们的荣幸。我们以努力创造条件,培养优秀的科研人才为己任。

  

RESEARCH INTERESTS (研究方向):

1. Drug discovery of anti-androgen receptor and anti-tumors; (新型抗雄激受体和抗癌药物研究)  

2. Design and synthesis of small molecules with important biological activities. (设计、合成生物活性分子

3. Clean Technology Industrialization Research in Chemical engineering(清洁工艺生产技术产业化研究)

  

PROFESSIONAL EXPERIENCE (工作经历):

2013- Present, Professor of Pharmacy, Researcher of Pharmaceutical Engineer,  

School of Pharmaceutical and Life Sciences, Changzhou University, China. (常州大学制药学院)  

2013- 2015, Visiting professorNanjing University of Traditional Chinese Medicine, (南京中医药大学)  

2012- Present, ResearcherCEO, Nanjing Hope-pharm Co.Ltd, China. (南京慧博生物科技有限公司)  

2006-2012, Researcher of Pharmaceutical Engineer, Associate Professor of Pharmacy, School of Pharmacy, Shanghai Jiao Tong University, China. (上海交通大学药学院)  

2009-2011, Visiting Scholar, Post doctoral Fellow,

Medical Center, Rochester University, New York, USA (美国罗切期特大学医学研究中心)

2001-2003,Senior Engineer, Senior Group Leader, JinTan Wish chem Co.,Ltd(金坛希望化工有限公司)

1992-2000, Chemical Engineer, Jiangsu Institute of Ecomones(江苏激素研究所)

1990-1992, Engineer Assistant, Fushun Petroleum & Chemical Corporation of China(中国石化公司抚顺分公司)

  

EDUCATIONBACKGROUND (教育背景):

2006,Ph.D. (Major: Medicine Chemistry), Shanghai JiaoTong University, China. (上海交通大学)

2000, M.S.(Major: Apply Chemistry), Nanjing University of Science & Technology, (南京理工大学)

1990, B.S. (Major: Organic Chemistry), Jiangsu Polytechnic University, China (江苏化工学院)

  

TEACHINGEXPERIENCE (授课经历):  

· Pharmaceutical Engineer制药工程” (for undergraduate students, 2013-2015), Changzhou University, China.

“Introduction to Pharmaceutical Engineering 制药工程专业概论” (for undergraduate students, 2013-2015), Changzhou University, China.

·“Pharmaceutical preparation engineering药物制剂工程” (for graduate students, 2013-2015) Changzhou University, China.

·“Experiment of medicine chemistry药物化学实验” (for undergraduate students, 2006-2012), Shanghai JiaoTong University, China. 

·“Total Synthesis of Natural Products 天然产物全合成” (for graduate students, 2006-2012), Shanghai JiaoTong University, China.

  

AWARDS AND RECOGNITIONS (获奖荣誉):

1. Innovative and entrepreneurial talent of Jiangsu Province(2015) (江苏省双创人才”)

2. The science and technology entrepreneurs of Nanjing (2015) (南京市科技创业家)

3. Invention & Entrepreneurship Award, China Association of Inventions2014(中国发明协会,发明创业奖-人物奖)

4. Third award of Technical invention, China Petroleum & Chemical Industry Federation (2014) (科技发明三等奖中国石油与化工联合会)

5. Overseas Entrepreneurial Talents of Jiaxing (2013) (创业嘉兴海外引进人才)

6. Leading Entrepreneurial and High-tech Talents of Nanjing (2012)(南京市321引进人才)

7. Third Award of Science and technology progress, Shanghai Pharmaceutical Association (2010). (科技进步三等奖,上海药学会)

8. Second Award of Teaching Achievement, Shanghai JiaoTong University (2012) (教学成果二等奖,上海交通大学)

9. Second Award of Science and technology progress, China Petroleum & Chemical Industry Federation (2009)(科技进步二等奖中国石油与化工联合会)

10. Star of Outlook Award for Young Scholars of Shanghai Jiao Tong University (2008) (晨星青年学者二等奖,上海交通大学)

11. Third Award of the Paper of Medicinal Chemistry Conference, Shanghai Pharmaceutical Association (2005), (科技论文三等奖,上海药学会)

12. Third award of No. 4 Zhou Paiyuan (HP) awarded by Ministry of Commerce of China.(1998), (HP应用成果奖三等奖,中国经贸部)

  

FUNDINGS (基金课题):  

1.Changzhou Science and Technology Development Funds, (Funds No: CE20162015) “Study on Industrialization and Application of Key Technology of Pyribenzoxim” (2016-2018, PI)).

常州市科技支撑计划,(基金号: CE20162015):“高效绿色除草剂嘧啶肟草醚关键技术产业化及应用研究,(2016-2017,主持).

2.The Jiangsu Province science and technology SME technology innovation fund project (grant No. BC2014026) “R & D of Modern medicine acne functionally active molecular and functional cosmetics” (2014-2016,PI)

江苏省科技型中小企业技术创新资金(代号BC2014026)现代中药祛痘功能活性分子及功能化妆品研发”(2013-2016, 主持).

3.Overseas Entrepreneurial Talents of Jiaxing A Innovative project “industrialization of Nano-molecular biological activity and functional cosmetics” (2014-2016, PI)

浙江省嘉兴市创新嘉兴·精英引领计划”A类创业基金:生物靶向纳米分子活性研究及功能化妆品产业化” (2014-2016, 主持).

4.High-tech leading talents of Changzhou C-special Innovative project “Study on the Novel Anti-androgen for Treatment of Prostate Cancer and Industrialization of Nature Good Food for the Prostate Health” (2014-2016,CO-PI)

江苏常州市龙城英才计划”C类特别创业基金:新型雄激素受体药物的创制研究及前列腺保健食品技术产业化” (2014-2016, 共同主持).

5.Leading Entrepreneurial and High-tech Talents of Nanjing Innovative project “Industrialization of Bispyribac sodium, a Herbicide with High-efficiency and Low Toxicity” (2013-2015,PI)

江苏南京市321人才创新创业基金:高效低毒水稻田除草剂双草醚新技术成果转化” (2013-2015,主持).

6.Sino-USA international collaborative project: “Preclinical Research on a Novel Anti-androgen ASC-J9” (2013-2016, CO-PI)).

国际合作项目:“国家一类新药ACS-J9临床前研究”(2013-2016, 共同主持)

7.Shanghai Minghang Science and Technology Development Funds, (Funds No: 2012MH166) “D & R on SIOC-Y-047, a Novel Oxadiazine Insecticide”(2012-2015, CO-PI)).

上海市闵行基金,(基金号: 2012MH166) :“ 噁二嗪类杀虫剂SIOC-Y-047创制研究,(2012-2015,共同主持).

  

SELECTED PUBLICATIONS(学术论文):  

1.Defeng Xu*, ShunzeGong, Xinhong Cai, Conciseand Convenient Synthesis of 4-(Trifluoromethylthio) aniline, AsianJ. Chem., 2017,29(11),91-92.

2.Qiang Dang, Wenbin Song, Defeng Xu, Yanmin Ma, Feng Li, JinZeng, Xinyang Wang, Luke Chang, DalinHe, Kaempferol suppresses bladder cancer tumor growth by inhibiting cellproliferation and inducing apoptosis, MOLECULARCARCINOGENESIS, 2015, 54( 9):831-840.

3.Defeng Xu*, Jing Guan, Xing Xu, Shunze Gong andHui Xu, A New Method for the Synthesis of Oxadiazine Insecticide Indoxacarb, J.Heterocyclic.Chem 2015, DOI:10.1002/jhet.2449

4.WenbinSong, Qiang Dang, Defeng Xu, Yule Chen, Guodong Zhu, Kaijie Wu, JinZeng, Qingzhi Long, Xinyang Wang, Dalin He, Kaempferol induces cell cyclearrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling, ONCOLOGY REPORTS, 2014,31(3):1350-1356.

5.Defeng Xu*, Xing Xu, Zhiling Zhu, A Convenient Synthesis of 4-Amino-2-fluoro-N-methyl-benzamide, J. Chem. Res.,2013,10,615-616.

6.Xu D, LinTH, Yeh CR, Cheng MA, Chen LM, Chang C, Yeh S. The wedelolactone derivativeinhibits estrogen receptor-mediated breast, endometrial, and ovarian cancercells growth. Biomed Res Int. 2014,713263.

7.SohSF, Huang CK, Lee SO, Xu D, Yeh S, Li J, Yong EL, Gong Y, Chang C. Determination of androgen receptor degradation enhancer ASC-J9(®) in mouse sera and organs with liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2014, 88:117-22.

8.Zhou,SW,Xu, DF* , Wang, ZQ, Zhu, ZL ,Zha, ZY , Fan, Y, Su, HK, An Efficient and Convenient Synthesis of4,6-Dichloro-2-methyl-5- nitropyrimidine, AsianJ. Chem., 2014,26(12), 3559-3561.

9.Defeng Xu*, Zhiling Zhu, Ziqiao Wang, A convenient synthesis of 4,6-dimethyl-2-(methylsulfonyl) pyrimidine, J.Chem. Res.,2013, 12, 720-722.

10.Defeng Xu*, Zhiling Zhu, HuiXu, Ziqiao Wang, A facile Synthesis of 4, 6-dimethoxy-2-methylsulfonyl-pyrimidine, Asian J.Chem.,2014, 26(1), 313-314.

11.Defeng Xu*, Ziqiao Wang, AFacile Synthesis of 4, 6-Di methoxy-methylsulfonylpyrimidine, Asian J. Chem.,2014, 26 (1),313-314.

12.MinLu,Shuwen Zhou, Jing Guan, Xing Xu, Yu Fan, Defeng Xu*, Synthesis of key intermediate of phosphonosulfonates (BPH-652), 1-(3-iodopropyl)-3-phenoxybenzeneAsian J. Chem., 2014, 26(22), 7619-7621.

13.Lin TH, Lee SO, Niu Y, Xu D,Liang L, Li L, Yeh SD, Fujimoto N, Yeh S, Chang C*.,Differential Androgen Deprivation Therapies with Anti-androgens Casodex/Bicalutamide or MDV3100/Enzalutamide versus Anti-androgen Receptor ASC-J9(R) Lead to Promotion versus Suppression of Prostate Cancer Metastasis. J .Biol Chem. 2013, 288(27):19359-69.

14.Hsu JW, Hsu I, Xu D, Miyamoto H, Liang L, Wu XR, Shyr CR, Chang C. Decreased tumorigenesis andmortality from bladder cancer in mice lacking urothelial androgen receptor. Am J Pathol. 2013, 182(5):1811-20.

15.Defeng Xu, Tzu-Hua Lin, Shaoshun Li, Jun Da, Xinquin Wen, Jiang Ding, Chawnshang Chang* and ShuyuanYeh*, Cryptotanshinone Suppresses Androgen Receptor-mediated Growth in Androgen Dependent and Castration Resistant Prostate Cancer Cells. Cancer Letters.2012, 316 (1), 11-22.

16.Defeng Xu, Tzu-Hua Lin, Shaoshun Li, Jing Zhang, Min Yin, Shuyuan Yeh*, and Chawnshang Chang*,TheSelective Inhibitory Effect of a Synthetic Tanshinone Derivative on Prostate Cancer Cells. The Prostate, 2012,72(7):803-16. (IF: 3.843).

17.Shinichi Yamashita, Kuo-PaoLai, Kun-Lung Chuang, Defeng Xu, Hiroshi Miyamoto, Tatsuo Tochigi, See-Tong Pang, Lei Li, Yoichi Arai, Hsing-Jien Kung, Shuyuan Yeh* and Chawnshang Chang*, ASC-J9® suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors. Neoplasia, 2012, 14 (1): 74-83.

18.Xiaohai Wang, Wen-Jye Lin, Kouji Izumi, Qi Jiang, Kuo-Pao Lai, Defeng Xu, Lei-Ya Fang, Tianjing Lu,Lei Li, Shujie Xia, and Chawnshang Chang, Increased Infiltrated Macrophages in Benign Prostatic Hyperplasia (BPH): ROLE OF STROMAL ANDROGEN RECEPTOR INMACROPHAGE-INDUCED PROSTATE STROMAL CELL PROLIFERATION. J. Biol. Chem.2012, 287: 18376-18385.

19.Qi Jiang, Shuyuan Yeh, Xiaohai Wang, Defeng Xu, Qiaoxia Zhang, Xinquin Wen, Shujie Xia, Chawnshang Chang et al. Targeting Androgen Receptor Leads to Suppression of Prostate Cancer via Induction of Autophagy. Journal of Urology, 2012. 188(4), 1361-1368.

20.Tianjing Lu, Wen-Jye Lin, KoujiIzumi, Xiaohai Wang, Defeng Xu, Lei-Ya Fang, Lei Li, Qi Jiang, Jie Jin, Chawnshang Chang, Targeting Androgen Receptor to Suppress Macrophage-induced EMT and Benign Prostatic Hyperplasia (BPH) Development. Molecular endocrinology.2012, 26(10):1707-15.

21.Rubing Wang, Runting Yin, WenZhou, Defeng Xu, Shaoshun Li.Shikonin and its derivatives: a patentreview. Expert opinion on therapeuticpatents.2012, 22 (9):977-97.

22.Jianzhong Zhang, Defeng Xu*,Jianpin Wu, Synthesis of 3-(2,2, 2-Trifluoroethoxy)-2 pyridine sulfonamide, Asian J. Chem.2010, 22 (1),826-828.

23.Li-Ming Zhao, Xie, Tian-Pe, He, Yu-Qin, De-Feng Xu, and Shao-Shun Li; Synthesis and antitumor activity of 6-and2-(1-substituted-thio-4-methylpent -3-enyl)-5,8-dimethoxynaphthalene-1,4-diones,Euro. J. Med. Chem.2009, 44(4), 1410-1414.

24.Defeng Xu, Li-Ming Zhao, Zhi-Qiang Mao,and Shao-Shun Li; Regioselective Phenyl Anion Transfer: Application to the Total Synthesis of (±)-Shikonin, Org. Prep. Proced. Int. 2008, 41(1),93-105.

25.Li-Ming Zhao, Defeng Xu, and Shao-Shun Li; Concise formal synthesis of (±)-Shikonin via a highlyalpha-regioselective prenylation of 1,4,5,8-tetra methoxynaphthalene-2-carbaldehyde,Letts.Org. Chem.2008, 53(3), 234-236.

26.Wen Zhou, DefengXu, Ai-Hong Zhao, and Shao-Shun Li; A Mild and Efficient Semi-Synthesis of Leucoacetates, J Indian Chem. Soc.2008, 85(1),1-3.

27.Li-Ming Zhao, Xie, Tian-Pe, He, Yu-Qin, De-Feng Xu, and Shao-Shun Li; Synthesisand antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthaquinones. Chin. Chem. Lett., 2008, 19(10), 1206-1208.

28.Ai-Hong Zhao, Defeng Xu, Wen Zhou, and Shao-Shun Li; A Convenient Synthesis of 2-Formyl-1,8:4,5-bis(methylenedioxy)naphthalene, J. Chem.Res.2007, 11, 647-648.

29.Defeng Xu, Peng-Jian Guan, and Shao-Shun Li; A convenient synthesis of 2-formyl- 1,4,5,8-tetramethoxynaph thalene, J. Chem. Res., 2006, 12, 779–780.

30.Defeng Xu, Xiao-Juan Guo, Zhao-Hui, Xu,and Shao-Shun Li; A Novel Total Synthesis of (±) ShikoninChin. Chem. Lett., 2006, 7, 871-873.

  

SELECTED PATENTS(专利):

1.DeFeng XuPYRIMIDYLSALICYLATECOMPOUND WITH NEW HERBICIDAL ACTIVITY, PREPARATION METHOD THEREFOR, AND USESTHEREOF AS HERBICIDE. WO2015081493 (A1)

2.DeFeng Xu, Health-care food for male and preparation method thereof. CN103859412 (B)

3.DeFeng Xu, Min Lu, Process for preparation of 1-(3-iodopropyl)-3-phenoxybenzene,CN 103641697.

4.DeFeng XuMethod for preparing 4-amino-2-fluoro-N-methylbenzamide, CN 103304439.

5.DeFengXu, Method for preparing 4, 6-dichloro-2-methyl-5-nitropyrimidine.CN103483268 (B)

6.DeFeng XuMethod for preparing dialkyl curcumin, CN 103254051

7.DeFeng XuA kind of man's health food and preparation method thereof, CN 103859412

8.DeFeng XuPlantcomposite gel for treating acne and method for manufacturing the same [Machine Translation]. CN 103041113.

9.DeFeng XuMedical composition comprising traditional Chinese medicines for treating acne and preparation method thereof, CN 102908602.

10.DeFeng XuYejun Ji, Shaoshun Li, Method for preparing herbicide bispyribac sodium, CN 101265235.

11.DeFeng XuShaoshun Li, Method for chemically synthesizing wedelolactone, CN 101235039.

12.Shaoshun Li, Wen Zhou, DeFeng XuAlkannin dimethyl ether with 6-side chain isomer, and its derivative andsynthetic method. CN 101182290

13.Shaoshun Li, WenZhou, DeFeng XuAihong Zhao, Method forsynthesis of Alkannin dimethyl ether derivatives, CN 101139287

14.Shaoshun Li, DeFeng XuTotalsynthesis of racemic Shikonin, CN 1686994.

15.DeFeng XuMacafermented wine and preparation method thereof, CN105602797.

16.DeFeng XuXingXu, Preparation method of paddy field herbicide pyriminobac-methyl, CN105272925

17.DeFeng XuHealthcaremaca oral solution and preparation method thereof, CN105168574

18.DeFeng XuMethodfor extracting and purifying monomeric macamide compounds from maca,CN105111098

19.DeFeng XuMacafunctional beverage and making method thereof, CN105077489.

20.DeFeng XuPlantcompound gel for treating chloasma and preparation method thereof, CN105055800

21.DeFeng XuThree-highreducing health care product and method for preparing the same, CN104940461

22.DeFeng XuFemalehealthcare food and preparation method thereof, CN104886576

23.DeFeng XuMacatablet and preparation method thereof, CN104687048

24.DeFeng XuPurificationmethod of enzalutamide, CN104610158

25.DeFeng XuEnzalutamidemicelle preparation and preparation method thereof, CN104546714

26.DeFeng XuMethodfor continuously producing herbicide 2,4-dichlorophenoxyacetic acid,CN104529757.

27.DeFeng XuPreparation method for efficiently purifying phacolysin bulk drugs, CN104387395

28.DeFeng XuMethod for preparing wedelolactone monomeric compounds extracted from eclipta,CN104193758

29.DeFeng XuPreparation method for novel insecticide indoxacarb, CN104193696

30.DeFeng XuPreparation method of novel oxadiazine pesticide SIOC-Y-047, CN104151260

31.DeFeng XuPreparation method for extracting and purifying tanshinone monomeric compounds from redsage root,CN103665094

32.DeFeng XuPreparationmethod of pyribenzoxim belonging to pyrimidinyl thiobenzoate herbicide,CN103319421 (A)

33.DeFeng XuTanshinoneimidazole compound and its preparation method and use, CN103232521

34.DeFeng XuTanshinonecompounds, preparation method and use thereof, CN103193860

  

社会兼职(Professional affiliations

江苏双创人才联合会副秘书长,现代农业科技专委会秘书长

江苏省生物技术协会特邀理事,中国发明家协会会员