陈新 简介

发布时间:2017-05-15浏览次数:198

Xin Chen陈新 博士/教授

CONTACT(联络信息):          

School of Pharmaceutical and Life SciencesChangzhou University

Changzhou, Jiangsu 213164, China

Tel:(0519) 86334598

Email:xinchen@cczu.edu.cn

  

RESEARCH INTERESTS(研究方向):

1.Drugdiscoveryfor treating infection and tumors;(新型抗生素和抗癌药物研究)      

2.Synthesis of small molecules with important biological activities.(具有重要生物活性有机小分子的合成方法研究)

  

PROFESSIONAL EXPERIENCE(工作经历):

2010-Professor of Chemistry    

School of Pharmaceutical and Life Sciences, Changzhou University, China. (常州大学制药学院)      

2004-2010Director of Small Molecule Synthesis Facility&Assistant Research Professor

Department of Chemistry, Duke University, North Carolina, USA. (美国杜克大学化学系)    

2001-2003SeniorResearch Scientist

TransTech Pharma Inc., North Carolina, USA. (美国TransTech Pharma制药公司)    

2000-2001Postdoctoral Research Associate    

Department of Chemistry, Duke University,North Carolina, USA (美国杜克大学化学系)      

1997-1999Postdoctoral Fellow    

Department of Entomology, University of California, Riverside, California, USA (美国加州大学河滨分校昆虫学系)      

1995-1997Associate Professor

Department of Chemistry, Tsinghua University, Beijing, China    (清华大学化学系)      

1993-1995Postdoctoral Researcher

Department of Chemistry, Tsinghua University, Beijing, China    (清华大学化学系)        

  

TEACHINGEXPERIENCE(授课经历):        

·“Medicinal Chemistry药物化学”(for undergraduate students, 2011-2016)

Changzhou University, China.

·“FDA Regulations for New Drugs新药认证” (for undergraduate students, 2010-2014)

Changzhou University, China.

·“New Drugs R&D新药研究与开发”(for graduate students, 2011-2016)

Changzhou University, China.

·“Design of Organic Molecules有机分子设计”(for undergraduate students, 1995-1997)

Tsinghua University, China.

·“Organic Synthesis有机合成”(for graduate students, 1995-1997)

Tsinghua University, China.

  

EDUCATIONBACKGROUND(教育背景):

1993, Ph.D. (Major: synthetic organic chemistry), Lanzhou University, China.    (兰州大学化学系)Advisor: Yulin Li        

1990, M.Sc. (Major: organic chemistry), Lanzhou University, China.      (兰州大学化学系)Advisor: Ziyi Zhang      

1987, B.Sc. (Major: organic chemistry), Lanzhou University, China. (兰州大学化学系)      

  

AWARDS AND RECOGNITIONS(获奖荣誉):

1Outstanding Researcher of Jiangsu Province(2014)      

(11届江苏省优秀科技工作者, 2014)      

2Top-Ten Excellent Researchers of Changzhou City (2014)      

(常州市十佳科技工作者, 2014)      

3Excellent Teacher of Changzhou University (2014)      

(常州大学2014年十佳师德标兵”)      

4Team award ofexcellent advisor for undergraduate thesis of Jiangsu Province (2012)

(2012年度江苏省高校本专科优秀毕业设计(论文)优秀毕业设计团队奖)      

5Excellent advisor of undergraduate thesis, Changzhou University (2011,2012 & 2015)    

(常州大学本科毕业论文优秀指导教师,201120122015)    

6Second-level talented scientist of “333High-levelTalent Training Program” of Jiangsu Province

(江苏省“333高层次人才培养工程第二层次培养对象) (2011-2015)      

7Innovative andentrepreneurial talentof Jiangsu Province (2009)

(江苏省双创人才”)

8Science and technology leader of “831 Talent Training Program” of Changzhou City (2009)

(常州市831高层次人才培养工程首批中青年科学技术带头人)

9Teamrecognitionaccomplishmentaward, TransTech Pharma Inc., USA (2003)      

(美国TransTech Pharma公司团队成就奖)    

10Science andtechnologyprogressprize (3rdplace), Ministry of Education of China (1997)      

(教育部科技进步奖三等奖)    

11Science andtechnologyprogressprize (2ndplace), Gansu Province(1996)      

(甘肃省科技进步奖二等奖)    

  

FUNDINGS (基金课题):      

1.National Science Foundation of Chinaproject (grant No. 21272029): “Study on novel inhibitors of type III secretion system forPseudomonasaeruginosa” (2013-2016, PI)      

国家自然科学基金面上项目(代号21272029): “绿脓杆菌III型分泌系统的新抑制剂研究” (2013-2016,主持)

2.National Science Foundation of China project (grant No. 81272982): “Structure-activity relationship study of Garcinol for oral cancer chemoprevention” (2013-2016, Co-PI)      

国家自然科学基金面上项目(代号81272982): “山竹醇在口腔癌化学预防中的构效关系研究” (2013-2016,合作主持)

3.Sino-USAinternational collaborative project: “Synthesis and screening of new inhibitorsagainstT3SS of pathogens” (2012-2014, PI)      

国际合作项目:“病原菌III型分泌系统新抑制剂的合成和筛选”(2012-2014,主持)

4.Technology Supporting Program of Jiangsu Province project: “Efficient sex pheromone technology and its application for pollution-controlling management of vegetable pests”(2012-2014, PI)      

江苏省科技支撑计划项目: “无公害防治蔬菜害虫的高效生物信息素技术及应用开发”(2012-2014,主持)      

5.National Science Foundation of China project (grant No. 29602004):“Study on new synthetic methods for oligonucleotides (1997-1999, PI)      

国家自然科学基金青年基金项目(代号29602004): “寡核甘酸新的化学合成方法研究” (1997-1999,主持)

  

SELECTEDPUBLICATIONS(学术论文):      

1.Chao-Ming Han, Xin-Ying Zhou, Jing Cao, Xin-Yan Zhang*,Xin Chen*.13,14-Dihydroxy groups are critical for the anti-cancer effects of garcinol.Bioorg. Chem. 2015, 60, 123-129.

2.Yan Li,William Hutchins, Xiaogang Wu, Cuirong Liang, Chengfang Zhang, Xiaochen Yuan, Devanshi Khokhani,Xin Chen, Yizhou Che, Qi Wang*, Ching-Hong Yang*. Derivatives of plant phenolic compound inhibits the type IIIsecretion system of Dickeya dadantii via HrpX/HrpY two-component signaltransduction and Rsm system.Molecular Plant Pathology, 2015, 16(2), 150-163.

3.Yu-Hui Luo, Bo Li, Xiao-Yang Yu, Chao-Ming Han, Xin-Xin Lu, Hong Zhang*,XinChen*. Self-assembly of four functional coordination polymers based on α-[P2W18O62]6-.Polyhedron, 2015, 85,705-711.            

4.Yu-Hui Luo, Ling-Ling Gu, Xiao-Yang Yu, Feng-XiaYue,Xin Chen*, Hong Zhang*. A novel3D self-catenated coordination polymer with multiform helical chains.Inorg. Chem. Commun. 2014, 40,176-180.        

5.Arun K. Shukla, Gerwin H. Westfield, Kunhong Xiao,Rosana I. Reis, Li-Yin Huang, Prachi Tripathi-Shukla, Jiang Qian, Sheng Li, AdiBlanc, Austin N. Oleskie, Anne M. Dosey, Min Su, Cui-Rong Liang, Ling-Ling Gu,Jin-Ming Shan,Xin Chen, RachelHanna, Minjung Choi, Xiao Jie Yao, Bjoern U. Klink, Alem W. Kahsai, Sachdev S.Sidhu, Pawel A. Penczek, Shohei Koide, Anthony A. Kossiakoff, Virgil L. WoodsJr., Brian K. Kobilka*, Georgios Skiniotis*, Robert J. Lefkowitz*.Visualization of arrestin recruitment by a Gprotein-coupled receptor.Nature, 2014, 512, 218-222.

6.Cuirong Liang, LinglingGu, Yang,Xin Chen*. Alternate synthesis of HSP90 inhibitor AT13387,Synth.Commun. 2014, 44, 2416-2425.

7.Yu-Hui Luo, Feng-Xia Yue,Xiao-Yang Yu,Xin Chen*, HongZhang*. Coordination polymers of lanthanide complexes with benzenedicarboxylato ligands.CrystEngComm,2013, 15, 6340-6348.

8.Yu-Hui Luo, Feng-Xia Yue, Xiao-Yang Yu, Ling-Ling Gu, Hong Zhang*, Xin Chen*. A series of entangled ZnII/CdIIcoordination polymers constructed from 1,3,5-benzenetricarboxylate acid and flexible triazole ligands.CrystEngComm,2013, 15, 8116-8124.

9.Fengxia Yue, Xiaoyang Yu, Yuhui Luo, Jiajun Yang,Xin Chen*, Hong Zhang*. A rare 4-connected neb topological framework based on Zn(II).J. Coordination Chem. 2013, 66,2843-2851.

10.Sheng-Qi Guo, Dan Tian, Yu-HuiLuo,Xin Chen*, Hong Zhang*. Twounusual 12-connected metal-organic coordination polymers with fcu net.J. Solid State Chem. 2013, 205,110-115.

11.Zheng-Yi Li, Hong-Zhao Ma, Chen Han, Hai-Tao Xi, Qi Meng,Xin Chen*,Xiao-Qiang Sun*. Synthesis of isothiocyanates by reaction of amines with phenylchlorothionoformate via one-pot or two-step process. Synthesis, 2013, 45, 1667-1674.

12.DevanshiKhokhani, Chengfang Zhang, Yan Li, Qi Wang, Quan Zeng, Akihiro Yamazaki,William Hutchins, Shan-Shan Zhou,Xin Chen*, Ching-Hong Yang*.Discovery of plant phenolic compounds that act as type three secretion systeminhibitors or inducers of fire blight pathogen Erwinia amylovora.Applied and Environmental Microbiology,2013, 79,5424-5436.

13.Kun HuYan-Jie QiJuan ZhaoHe-Fei JiangXin Chen*Jie Ren*.Synthesis and biological evaluation of novel sulforaphanederivatives as potential antitumor agents.Eur. J. Med. Chem. 2013, 64, 529-539

14.Jie Ren, Juan Zhao, Yong-Sheng Zhou, Xian-Hua Liu,Xin Chen*, Kun Hu*. Synthesis andantitumor activity of novel 4-aminoquinoline derivatives.Medicinal Chemistry Research, 2013, 22, 2855-2861.

15.Xin Chen,Xinyan Zhang, Ye Lu, Joong-Youn Shim, Shengmin Sang, Zheng Sun*, Xiaoxin Chen*. Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced Hamster Cheek Pouch Carcinogenesis by a 5-Lipoxygenase Inhibitor, Garcinol.Nutrition & Cancer2012, 64,1211-1218.

16.Jie Ren, Hong Cheng, Wen QunXin,Xin Chen*, Kun Hu*. Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells.Oncology Reports, 2012, 28,1719-1726.

17.Jie Ren, Hua-Jin Xu, Hong Cheng, Wen-Qun XinXin Chen*, Kun Hu*. Synthesis and antitumor activity of Formononetin nitrogen mustard derivatives.Eur. J. Med. Chem. 2012, 54,175-187.

18.Kun Hu, Lin Wu, Wen-Qun Xin,Xin Chen*, Jie Ren*.Synthesis and biological evaluation of anticancer activity for novel4β-amino oxadiazole derivatives of podophyllotoxin. Bioorg. Med. Chem. Lett. 2012,22, 4778-4782.

19.Tian-Li Chen, Xiao-Yang Yu, Xiang Zhao, Yu-Hui Luo, Jia-Jun Yang, HongZhang*,Xin Chen*. Syntheses, structures and luminescence properties of two series of 3D lanthanidecoordination polymers based on benzimidazole-5,6-dicarboxylic acid and oxalate. Inorg. Chem. Commun. 2012, 18,74-77.        

20.Xiang Zheng, Sheng-Qi Guo, Xiao-Yang Yu, Ju-Kun Hu, Yu-Hui Luo, HongZhang*,Xin Chen*. Two zinc(II)coordination polymers based on a benzenedicarboxylic acid derivative:synthesis, crystal structures and luminescent properties.Inorg. Chem. Commun. 2012, 18, 29-33.        

21.Akihiro Yamazaki, Jin Li, QuanZeng, Devanshi Khokhani, William C. Hutchins, Angela C. Yost, Eulandria Biddle,Eric J. Toone,Xin Chen*,Ching-Hong Yang*. Derivatives of plant phenolic compound affect thetype III secretion system ofPseudomonasaeruginosavia a GacS/GacA two component signal transduction system. Antimicrob. Agents Chemother.2012, 56, 36-43.        

22.Xin Chen*, Zhengyi Li, Xiaoqiang Sun, Hongzhao Ma, Xiaoxin Chen, Jie Ren, Kun Hu. New method for synthesis of sulforaphane and the related isothiocyanates.Synthesis, 2011, 3991-3996.

23.Bidong D. Nguyen, Doreen F. Cunningham, Xiaofei Liang,Xin Chen, Eric J. Toone, Christian R.H. Raetz, Pei Zhou, Raphael H. Valdivia*.Lipooligosaccharide is required for the developmental transition of replicative Reticulate Bodies to infectious Elementary Bodies inChlamydiatrachomatis. Proc. Natl. Acad. Sci. USA, 2011, 108, 10284-10289.

24.Chuljin Lee,Xiaofei Liang,Xin Chen, Daina Zeng, Sang Hoon Joo, Hak Suk Chung, Adam W. Barb, Shauna M. Swanson, Robert A. Nicholas, Yaoxian Li, Eric J. Toone*, Chris Raetz*, Pei Zhou*.Species-specific and Inhibitor-dependent Conformations of LpxC--Implication for Antibiotic Design.Chemistry& Biology,2011, 18,38-47.      

25.Xiaofei Liang, Chul-Jin Lee,Xin Chen,Hak Suk Chung,Daina Zeng,Christian R. H. Raetz,Yaoxian Li, PeiZhou*,Eric J. Toone*.Syntheses, Structures and Antibiotic Activities of LpxC Inhibitors Based on the Diacetylene Scaffold. Bioorg. Med. Chem. 2011, 19, 852-860.              

26.Artak Tovmasyan, Zrinka Rajic,Ivan Spasojevic, Julio S. Reboucas,XinChen, Huaxin Sheng, David S. Warner, Ludmil Benov, Ines Batinic-Haberle*.Methoxy-derivatization of alkyl chainsincreases the efficacy of cationic Mn porphyrins.Synthesis, characterization, SOD-likeactivity, and SOD-deficientE. colistudy ofmeta Mn(III)N-methoxyalkylpyridylporphyrins. J. Chem. Soc. Dalton Trans.2011, 40, 4111-4121.              

27.Warren S. Warren*, Elizabeth Jenista, RosaTamara Branca,Xin Chen.Increasinghyperpolarized spin lifetimes through true singlet eigenstates.Science,2009,323, 1711-1714.

28.J. R. Aldrich*, A. K. Hrimian,X.Chen, M. J. Camp. Semiochemically based monitoring of the invasion of thebrown marmorated stink bug and unexpected attraction of the native green stinkbug (Heteroptera: Pentatomidae) in Maryland.Florida Entomologist, 2009, 92, 483-491.

29.John J. Arnold, Yash Choksi,XinChen, Atsushi Shimazaki, John Hatten, Eric J. Toone, David L. Epstein,Pratap Challa*.Eyedropscontaining SA9000 prodrugs result in sustained reduction in intraocularpressure in rabbits.J. Ocular Pharmacology & Therapeutics,2009, 25, 179-186.

30.Yan Li, Quan Peng, Dija Selimi, Qi Wang, Amy Charkowski,Xin Chen, Ching-Hong Yang*. The plantphenolic compoundp-coumaric acidrepresses gene expression in theDickeyadadantiitype III secretion system. Applied& Environmental Microbiology,2009,75, 1223-1228.