任杰 简介

发布时间:2017-05-15浏览次数:114

任杰 博士 副教授

药学专业负责人/教研室主任

CONTACT

School of Pharmaceutical and Life Sciences(制药与生命科学学院)

Changzhou University(常州大学)

Changzhou, Jiangsu 213164, China      

Tel:(0519) 86330162    

E-mail: renjie@cczu.edu.cnrenjie2006@163.com

  

PROFESSIONAL EXPERIENCE

  

Changzhou University(常州大学), since 2007.05  

  

EDUCATIONAL BACKGROUND

Kyung Hee University (庆熙大学,韩国首尔),Ph.D.(2007)    

Shenyang Pharmaceutical University (沈阳药科大学),M.S.(2003)    

Shenyang Pharmaceutical University (沈阳药科大学), B.S(2001)      

  

RESEARCH INTERESTS

Pharmacology    

Medicinal Chemistry

  

AWARDS AND RECOGNITIONS

Excellent advisor of undergraduate thesis for Class of 2012,  Changzhou University       .    

(常州大学2012届本科毕业论文优秀指导教师)    

Outstanding young backbone teacher of “Qing Lan Project” of Jiangsu  Province (2012)    

(江苏省青蓝工程优秀青年骨干教师)(2012)    

Excellent guidance team of undergraduate thesis for Class of 2012, Jiangsu Province       .    

江苏省2012届优秀毕业论文指导团队,江苏省教育厅,一等奖

Excellent teacher, Changzhou University.(2012)    

常州大学优秀教师(2012)    

  

FUNDINGS

 Changzhou Basic Research Program (Application Program), (2013-2015, PI)    

常州市应用基础研究项目(2013-2015),主持人

国家六类新药临床前研究开发(企业合作项目)(2013年),主持人

National Science Foundation of China project (grant No. 21202012 ), (2012-2015, PI)    

国家自然科学基金青年基金(2012-2015),主持人

2010 Industry for Attracting Ph.D. Scientists Program of Jiangsu Province, (2010,PI)    

江苏省企业博士集聚计划资助基金(2010),主持人

Changzhou University Talent Introduction Fund, (2007,PI),    

常州大学人才引进基金(2007),主持人

  

RECENT PUBLICATIONS

1.“DMPPQA, a novel angiogenesis inhibitor, induces apoptosis in humancolon cancer HCT-116 cells and HUVECs”JieRen*, Hefei Jiang, Juan Zhao, Wenqun Xin, YuanyuanXu, Xin Chen and Kun Hu*Cell Biology International2014doi:10.1002/cbin.10209.      

2.“Biotransformation of 20(S)-protopanaxadiol by Aspergillusniger AS 3.1858 ”Guang-tong Chen, Xue Yang, Jianlin Li, HongjuanGe, Yan Song, JieRen*Fitoterapia201391256-260.    

3.“Synthesis and biological evaluation of novel sulforaphane derivatives as potential antitumor agents”Kun HuYan-jie QiJuan ZhaoHe-fei JiangXin Chen*JieRen*European Journal of Medicinal Chemistry201364529-539.    

4.“Synthesis and antitumor activity of N-sulfonyl-3,7-dioxo-5-cholan-24-amides,ursodeoxycholic acid analogues”JieRen, Yongchao Wang, Junliang Wang, Jun Lin, KunWei, Rong HuangSteroids20137853-58.    

5.“Synthesis and biological evaluation of anticancer activity for novel 4β-amino oxadiazole derivatives of podophyllotoxin”JieRenLin WuWen-QunXinXin ChenKun Hu*Bioorganic & Medicinal Chemistry Letters2012224778-4782.    

6.“Synthesis and antitumor activity of formononetin nitrogen mustard derivatives”JieRenHua-Jin XuHong ChengWen-QunXinXin ChenKun Hu*European Journal of Medicinal Chemistry201254175-187

7.“Apoptosisinduction of 7-piperazinethylchrysin in HCT-116 human colon cancer cells”JieRenHong ChengWen-QunXinXin ChenKun Hu*Oncology Report2012281719-1726.    

8.“Synthesis and antitumor activity of novel 4-aminoquinoline derivatives”JieRen, Juan Zhao, Yong-Sheng Zhou, Xian-HuaLiu, Xin Chen,Kun Hu*Medicinal Chemistry Research2012DOI 10.1007/s00044-012-0283-8.2013222855-261.    

9.“New method for synthesis of sulforaphane and the related isothiocyanates”XinChenZhengyi LiXiaoqiang SunHongzhao MaXiaoxin ChenJieRenKun HuSynthesis20113991-3996

10.“Antitumor activity of dichloromethane extracts from Salvia plebeia and induction of apoptosis on K562”RenJiePan Sha-shaLu Xu-zhangZhou Min Hu Kun*Chinese Herbal Medicines20103(1)36-40

11.“Synthesis and antitumor activity of liquiritigeninthiosemicarbazone derivatives”Kun HuZe-Hua YangSha-Sha PanHua-Jin XuJieRen*European Journal of Medicinal Chemistry2010453453-3458

12.“Synthesis and cytotoxicity of novel chrysin derivatives”Kun HuWei WangHong ChengSha-Sha PanJieRen*Medicinal Chemistry Research201020(7)838-846

13.“Anti-inflammatory effect of α-linolenic acid and its mode of action through the inhibition of nitric oxide production and iNOS gene expression via NF-κB and MAP kinase pathways”RenJie Chung Sung-Hyun*Journal of Agricultural and Food Chemistry2007(13)5073-5080

14.“In vivo and In vitro anti-inflammatory effects of α-linolenic acid isolated fromActinidiapolygama fruits”RenJieHan Eun-Jung Chung Sung-Huyn*Archives of Pharmacal Research2007 30708-714

15.“Polyphenol Compounds from VitisthunbergiiSieb et Zucc” De-Qiang Dou, JieRen, Maggie Cooper, Yue-Hua He, Yu-PingPei, Yoshiaki Takaya, MasatakeNiwa, Ying-Jie Chen, Xin-Sheng Yao and Ren-Ping Zhou, Journal of Chinese Pharmaceutical Sciences200312(2)57-59.    

16.“A New Compound from Forsythia Suspensa (Thunb.) Vahl with Antiviral Effect onRSV”. Guo-Gang Zhang, Shao-Jiang SongJieRen and Sui-XuXu*Journal of Herbal PharmacotherapyTM20022(3)35-40.    

17.“Ocotillone-type Ginsenoside from Leaves of Panax ginseng”. De-Qiang Dou, Ying Chen, JieRen,        Yu-Ping              Pei       and Ying-Jie Chen*Journal of Chinese Pharmaceutical Sciences, 2002, 11(4), 119-121.

18.“鬼臼毒素衍生物OAMDP诱导Hela细胞凋亡,任杰,辛文群,陈新,胡昆*中国药科大学学报201344(3)267-271.    

19.“刺芒柄花素氮芥衍生物的合成及抗肿瘤活性,胡昆,徐华金,辛文群,陈新,任杰*中国药科大学学报201243(2)113-119.    

20.“4β-(1,3,4-噁二唑-2-氨基)鬼臼毒素衍生物的合成及其抗癌活性” ,胡昆,吴琳,辛文群,陈新,任杰*沈阳药科大学学报201229(6)427-433.    

21.“木犀草素Mannich碱衍生物的合成及其抗癌活性研究,任杰,潘莎莎,程虹,胡昆*中国新药杂志201120(8)743-747

22.“甘草素缩胺硫脲类衍生物的合成及抗癌活性,任杰,潘莎莎,胡昆*,沈阳药科大学学报,201128(3): 192-197.    

23.“白杨素衍生物的合成及其抗肿瘤活性,任杰,程虹,王炜,胡昆*,中国药科大学学报,201142(3)206-212.    

24.“金色草素的全合成,胡昆,刘显华,任杰*,合成化学,201119(1): 115-117.    

25.“±-二氢槲皮素的全合成,胡昆,王振山,刘显华,任杰*,化学试剂,201133(1): 82-84.    

26.“三粒小麦黄酮的全合成,胡昆,王炜,任杰*,天然产物研究与开发,201022(6): 1028-1030.    

27.“天然产物Thienamycin的全合成研究进展,胡昆,王振山,任杰*,化工技术与开发,201039(3)19-26.    

28.“白杨素Mannich碱衍生物的合成及其抗癌活性,胡昆,王炜,任杰*,沈阳药科大学学报,201027(6): 448-452.    

29.“2-氨基-57-二甲氧基-124-三嗪并【15-α】嘧啶的合成及工艺优化,胡昆,宁红锋,任杰*,化学世界,201051(7): 418-420.    

30.“甘草素的合成及抗癌活性,胡昆,杨泽华,刘显华,任杰*,合成化学,201018(4): 513-516.    

31.“α-亚麻酸的体外抗炎作用机制研究,任杰,杨泽华,郑圣顯,胡昆*,云南大学学报,200931: 419-426.    

32.“匹多莫德的合成,胡昆,王振山,任杰*,中国医药工业杂志,200940(12): 883-884.    

33.“天然产物Quadrone的全合成进展,胡昆,杨泽华,任杰*,江苏工业学院学报,200921(3): 73-78.    

34.“橙皮素的全合成,胡昆,杨泽华,任杰*,云南大学学报,200931: 427-42.    

35.“高效液相色谱法测定人参提取物及其胶囊中人参皂甙Rb-1的含量,任杰,窦德强,赵春杰,裴玉萍,陈英杰*人参研究,20033: 5-9.    

36.“商品人参根的化学成分研究,窦德强,任杰,陈颖,裴玉萍,陈英杰*中国中药杂志2003 6.    

  

PATENT

1.“高纯46-二甲氧基-2-((苯氧基羰基)氨基)-嘧啶制备方法,胡昆,高学明,宋国强,蒋军,任杰,专利号:ZL 200810243711.6.    

2.“萝卜硫素的合成方法,陈新,孙小强,李正义,任杰,胡昆,专利号:ZL 2011 1 0162525. 1

3.“萝卜硫素衍生物及其制备方法和用途,胡昆,祁燕杰,任杰,陈新,赵娟,专利申请号:201210296425.2.已授权。

4.“新型抗菌剂酰基苯氧乙酸、酰基肉桂酸及其制备方法,陈新,张成芳,董爱玲,周珊珊,赵丽,任杰,胡昆,专利申请号: 201210222626.8.    

5.“4-胺基噁二唑表鬼臼毒素衍生物及其制备方法和用途,胡昆,任杰,吴琳,辛文群,专利申请号:201110362604.7.专利公开号:CN102229563

6.“4-氨基喹啉衍生物及其制备方法和用途,胡昆,任杰,刘显华,程虹专利申请号:201110104802.3.专利公开号:CN102229563

7.“酰基苯氧乙酸类化合物及其制备方法,陈新,张成芳,董爱玲,周珊珊,赵丽,任杰,胡昆,专利申请号:201310467090.0)

8.“肉桂羟肟酸类化合物及其制备方法,陈新,张成芳,董爱玲,周珊珊赵丽,任杰,胡昆,专利申请号:201310466747.1