徐华栋 简介

发布时间:2017-05-15浏览次数:131

Huadong XU 徐华栋 博士 研究员 硕导

CONTACT:

School of Pharmaceutical and Life Sciences

Changzhou University(常州大学制药与生命科学学院)

Changzhou, Jiangsu 213164, China

Cell: 15861150838

Email Addresshdxu@cczu.edu.cn

  

RESEARCH INTERESTS:

Organic methodology research by Organometallic Chemistry and Sugar Chemistry.

(有机方法学研究,重点运用金属有机化学方法和糖化学方法)

Drug research and development for treating cancers.

(新型抗癌药物的研究)

  

FUNDINGS:

2016国家自然科学基金面上项目(项目批准号:21672027

2013国家自然科学基金面上项目(项目批准号:21272077

  

PROFESSIONAL EXPERIENCE:

2012-presentProfessor

School of Pharmaceutical and Life Sciences, ChangzhouUniversity, China.

2010-2012Associate Professor

East China NormalUniversity, Shanghai. (华东师范大学)

2009-2010Senior Research Scientist

PharmaResources ShanghaiCO. LTD. (上海鸿博智源医药研究有限公司)

2007-2009Postdoctoral Research Associate

Chemistry Department,University of Wisconsin-Madison, USA. (威斯康星大学-麦迪逊分校)

2003-2007Teaching Assistant and Research Assistant

Chemistry Department,University of Illinois at Chicago, USA. (伊利诺依大学-芝加哥分校)

2000-2003Assistant Researcher

Daiwei Ma’ sResearch Group, Shanghai Institute of Organic Chemistry, Chinese Academy ofSciences (中国科学院上海有机化学研究所)

  

EDUCATIONAL BACKGROUND:

2007Ph.D in Organic Chemistry,Chemistry Department, University of Illinois at Chicago, USA. (伊利诺依大学-芝加哥分校)

2000Master in Organic Chemistry, East China University of Science and Technology (Shanghai, P. R. China)(华东理工大学)

1998Bachelor in Chemistry, Lanzhou University (兰州大学)

  

SELECTED PUBLICATIONS:

1.Hua-DongXu*,Hao Zhou,Ying-Peng Pan, Xin-Tao Ren, Hao Wu, Mei Han, Run-Ze Han,Mei-Hua Shen*.StereoselectiveSynthesis of Polycycles Containing an Aziridine Group: Intramolecularaza-Diels-Alder Reactions of Unactivated 2H-Azirines with UnactivatedDienes.Angew. Chem., Int. Ed.2016,55(07),2540-2544.Published online: January 12, 2016

2.Hao Zhou, Mei-Hua Shen*Hua-Dong Xu*.Evolution of the Aza-Diels-Alder reaction of 2H-azirines.Synlett Review2016,27, 2171-2177 

3.Hua-DongXu*,Hao Wu, Chun Jiang, PengChen, Mei-Hua Shen*. Chemo-, regio-, and stereoselective hydroboration ofconjugated enyne alcohol/amine: facile synthesis ofZ,Z-/Z,E-1,3-dien-1/2-ylboronic ester bearing hydroxyl/amino group.Tetrahedron Lett.2016,57(26), 2915-2918.

4.Xiao-Long Lu, Ya-Ting Liu,Qiang-Xia Wang, Mei-Hua Shen*, Hua-Dong Xu*. Straightforwardregioselective construction of 3,4-dihydro-2H-1,4-thiazine by rhodium catalysed[3+3] cycloaddition of thiirane with 1-sulfonyl-1,2,3-triazole: a pronouncedacid additive effect.Org. Chem. Front.,2016,3(6),725-729.

5.Mei-Hua Shen*, Mei Han, Hua-DongXu*. One-Pot Conversion of N‑Allyl-α-cyano Esters to α‑Allyl-α-cyano Lactamsthrough a Hydrolysis/Ketene Formation/Cyclization/Claisen RearrangementSequence.Org. Lett.2016,18(5), 889-891.

6.Hua-DongXu*,Hao Zhou, Ying-Peng Pan,Xin-Tao Ren, Hao Wu, Mei Han, Run-Ze Han, Mei-Hua Shen*.Stereoselective Synthesis of PolycyclesContaining an Aziridine Group: Intramolecular aza-Diels-Alder Reactions ofUnactivated 2H-Azirines with Unactivated Dienes.Angew. Chem., Int. Ed.2016,55(07),2540-2544.Published online: January 12, 2016

7.Mei-Hua Shen*, Ke Xu, Chu-Han Sun, Hua-Dong Xu. Facile synthesis ofaza-spirocyclopropanyl oxindoles by the reaction of 3-(2-bromoethyl)-indolewith2,3-dimethylimidazole-1-sulfonylazide triflate.Org. Biomol. Chem., 2016,14(04), 1272-1276.

8.Mei-Hua Shen*, Ke Xu, Chu-Han Sun, Hua-Dong Xu*.Stereoselective Construction of Bridged trans-aza-Bicyclo[7/6,3/2,1]alkenylImines through Ring Expansion aza-Cope Rearrangement.Org. Lett.2015,17(22), 5598-5601.

9.Mei-Hua Shen,* Xiao-LongLu, Hua-Dong Xu*. Copper(II) acetatecatalysed ring-opening crosscoupling of cyclopropanols with sulfonyl azides. RSC Adv. 2015,5(120),98757-98761.

10.Hua-Dong Xu*, Ying-Peng Pan, Xin-TaoRen, Ping Zhang,Mei-Hua Shen*.A one-pot construction of acridones by rhodium catalyzed reaction ofN-phenyl-2-(1-sulfonyl-1H-1,2,3-triazol-4-yl)aniline.Tetrahedron Lett.2015,56(48), 6734-6737.

11.Mei-Hua Shen*, Ke Xu, Chu-Han Sun, Hua-Dong Xu*.The Reaction of2,3-Dimethylimidazole-1-sulfonyl Azide Triflate with 3-Substituted Indoles:Reactivity and Scope.Org. Lett.2015,17(15), 3654-3657.

12.Xian-Hua Pan*, Pan Jiang,Zhi-Hong Jia, Ke Xu, Jing Cao, Chang Chen, Mei-Hua Shen, Hua-Dong Xu*. Expedient catalytic construction ofazabicyclo[4.1.0]/[5.1.0] carbaldehydes via intramolecular cyclopropanation.Tetrahedron2015,71(32),5124-5129.

13.Mei-Hua Shen*,Ying-Peng Pan, Zhi-Hong Jia, Xin-Tao Ren, Ping Zhang, Hua-Dong Xu*.An efficientapproach to 1,2,3-trisubstituted indoleviarhodium catalyzed carbene Csp3–Hbond insertion.Org. Biomol. Chem., 2015,13(17), 4851-4854.

14.Hua-Dong Xu*,Zhi-Hong Jia, Ke Xu, Hao Zhou, Mei-Hua Shen*. One-Pot Protocol toFunctionalized Benzopyrrolizidine Catalyzed Successively by Rh2(OAc)4 andCu(OTf)2: A Transition Metal–Lewis Acid Catalysis Relay.Org. Lett.2015,17(01), 66-69.

15.Hua-Dong Xu*,Ke Xu, Hao Zhou, Zhi-Hong Jia, HaoWu, Xiao-Long Lu, Mei-Hua Shen*.Ring-Strain-DrivenCatalytic Carbene Formation-Cyclopropanation-Aza-Cope Rearrangement Cascade: AFacile Entry to Fused Dihydroazepines from 1,3-Dienyltriazoles.Synthesis2015,47(05), 641-646.

16.Hua-Dong Xu*,Ke Xu, Qing Zheng, Wei-Jie He, Mei-Hua Shen*,Wen-Hao Hu. Step-economy etherification of acylated alcohols.Tetrahedron Lett.2014,55(50), 6836-6838.

17.Hua-Dong Xu*, Ke Xu, Zhi-Hong Jia, HaoZhou, Pan Jiang, Xiao-Long Lu, Ying-Peng Pan, Hao Wu, Yun Ding, Mei-Hua Shen*,Xian-Hua Pan. Substituent Enabled Divergent Synthesis of N-Heterocycles: aMetal Carbene Approach Involving Intramolecular Carbene Interception.Asian J. Org. Chem.2014,3(11), 1154-1158.

18.Hua-Dong Xu*, Zhi-Hong Jia, Ke Xu, MeiHan, Sai-Nan Jiang, Jing Cao, Jia-Cheng Wang, Mei-Hua Shen*. Copper-CatalyzedCyclization/aza-Claisen Rearrangement Cascade Initiated by KetenimineFormation: An Efficient Stereocontrolled Synthesis of α-Allyl Cyclic Amidines.Angew. Chem., Int. Ed.2014,53(35),9284-9288.Published online: July 2, 2014

19.Hua-Dong Xu*, Mao-Qiang Cai, Wei-Jie He,Wen-Hao Hu, Mei-Hua Shen*. Interception of benzyne with thioethers:a facileaccess to sulfur ylides under mild conditions.RSC Adv.2014,4(15), 7623-7626.

20.Hua-Dong Xu*, Ren-Wei Zhang, Xiaoxun Li,Suyu Huang, Weiping Tang, Wen-Hao Hu. Rhodium-Catalyzed Chemo- andRegioselective Cross-Dimerization of Two Terminal Alkynes.Org. Lett.2013,15(04), 840-843.

21.Na Liu, Hao-Yuan Wang, WeiZhang, Zhi-Hong Jia, Ilia A. Guzei, Hua-DongXu*, Weiping Tang*. Stereoselective Halocyclization of Alkenes With N-AcylHemiaminal Nucleophiles.Chirality2013,25(11), 805-809.