王悦 简介

王悦，副教授，2006年中南大学湘雅医学院生理学硕士研究生毕业，2016年美国内华达大学医学院访问学者。热爱教育事业，任教20余年，对教育事业有着深厚的感情，目前承担药学专业、生物医学工程专业基础课程的教学，教学效果受到学生好评。被常州大学评为“优秀教师”、“优秀班主任”，2018年获常州大学高等教育教学成果奖二等奖（排名第一），2021年获常州市第十六次自然科学优秀科技论文（第一作者）三等奖。

Email: wangyuebj2003@cczu.edu.cn

研究方向：

天然产物（药物）的提取开发、合成转化及评价

天然产物与心肺疾病的基础及临床研究

教学科研项目：

主持横向课题1项（KYH21020419），以主要参与人参与国家自然科学基金重点项目1项（项目编号11532003），国家自然科学基金面上项目2项（项目编号12272063、31670950）、国家自然科学基金青年项目2项（项目编号21202012、11402037）。校级教研课题结题2项。

主要研究成果有：

1.       Tan M, Huang W, Wang Y et al. Integrin-β4 regulates the dynamic changes of phenotypic characteristics in association with epithelial-mesenchymal transition (EMT) and RhoA activity in airway epithelial cells during injury and repair. International Journal of Biological Sciences, 2022; 18(3): 1254-1270.

2.        Wang Y, Zhong B, Wu Q, Zhu T, Zhang M. Aldosterone Contributed to Pulmonary Arterial Hypertension Development via Stimulating Aquaporin Expression and Pulmonary Arterial Smooth Muscle Cells Proliferation. Pharmacology, 2020, 105: 405-415.

3.        Wang Y, Wang A, Zhang M, Zeng H, Lu Y, Liu L, Li J, Deng L. Artesunate attenuates airway resistance in vivo and relaxes airway smooth muscle cells in vitro via bitter taste receptor-dependent calcium signalling. Experimental Physiology, 2019, 104: 231-243.

4.        Wang Y, Zhang Y, Zhang M, Li J, Pan Y, Liu L, Deng L. Saponins of Dioscorea Nipponicae Inhibits IL-17A-Induced Changes in Biomechanical Behaviors of In Vitro Cultured Human Airway Smooth Muscle Cells. Journal of Engineering and Science in Medical Diagnostics and Therapy, 2019, 2(011002): 1-7.

5.        Wang Y, Tan M, Ouyang H, Deng L. Effects of ozone stimulation of bronchial epithelial cells on proliferation and collagen synthesis of co cultured lung fibroblasts, Experimental and Therapeutic Medicine. 2018, 15: 5314-5322.

6.        张艺凡，王悦，刘磊，李晶晶，邓林红. 青蒿琥酯对小鼠气道阻力及气道平滑肌牵张力的效应研究. 生物医学工程研究，2017, 36(3): 191-196.

7.        Chen J, Deng L, Dreymüller D, Jiang X, Long J, Duan Y, Wang Y, Luo M, Lin F, Mao L, Müller B, Koller G, Bartsch JW. A novel peptide ADAM8inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models. Scientific Reports, 2016, 6(1): 1-13.

8.        Wang Y, Lu Y, Luo M, Shi X, Pan Y, Zeng H, Deng L. Evaluation of pharmacological relaxation effect of the natural product naringin on in vitro cultured airway smooth muscle cells and in vivo ovalbumin-induced asthma Balb/c mice. Biomedical Reports, 2016, 5: 715-722.

9.        Wang Y, Deng L, Mariam AB, Duan D. Oxidative Stress Upregulates the Calcium-activated Chloride Channels ANO1 in Human Pulmonary Artery Endothelial Cells. 2016 International Conference of Physiological Sciences, Beijing, China, 2016.9.28-2016.9.30.

10.    王悦，张艺凡，邓林红. 哮喘病理机制中臭氧应激对气道上皮细胞增殖和分泌IL-17A的影响, 2016中华医学会第十届全国哮喘学术会议, 广州, 2016.11.24-2016.11.26.

11.    Deng L, Lu Y, Wang Y, Luo M, Shi X, Pan Y. Naringin as Natural Fruit Product and Bitter Taste Agonist Induces Relaxation of Airway Smooth Muscle Cells via Intracellular Calcium Signaling, American Thoracic Society (ATS) 2016 International Conference, San Francisco, United States, 2016.5.13-2016.5.18.

12.    Zeng H, Wang Y, Luo M, Shi X, Lu Y, Pan Y, Deng L. Bitter taste receptor agonist (quinine) induces traction force reduction and calcium flux increase in airway smooth muscle cells from ovalbumin-sensitized and challenged rats. Journal of Advances in Biological Engineering and Technology, 2015, 2:20-27.

13.    Xu F, Wang Y, Luo M, Pan Y, Deng L. Stiffness of substrate influences the distribution but not the synthesis of autophagosomes in human liver (LO2) cells. Journal of Advances in Biological Engineering and Technology, 2015, 2:1-12.

14.    Qiu G, Xie X, Xu F, Shi X, Wang Y, Deng L. Distinctive pharmacological differences between liver cancer cell lines HepG2 and Hep3B. Cytotechnology,  2015, 67(1):1-12.

15.    Wang Y，Zhang M，Deng L，Exposure to ozone stress induces loss of homeostasis of human bronchial epithelial cells co-cultured with lung fibroblasts via regulation of cytokines associated with proliferation and collagen synthesis. 呼吸重大疾病转化医学学术论坛,广州,2014.11.27-2014.11.30.